Rodt T, von Falck C, Halter R, Ringe K, Shin HO, Galanski M, Borlak M (2009) In vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice. Pierce MC, Javier DJ, Richards-Kortum R (2008) Optical contrast agents and imaging systems for detection and diagnosis of cancer. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. Small Animal Positron Emission Tomography.Single Photon Emission Compute Tomography.With the ability to reliably track the metastasis and proliferation of small numbers of cancer cells, and specific subsets of cancer cells, will come new knowledge of the behavior of these cells in a relatively undisturbed environment.

CSC studies should take advantage of advanced imaging technology to increase our understanding of the CSC model, dormancy, tumor growth, and metastasis. Traditionally, the assays used to identify and examine CSC are labor-intensive, time-consuming, invasive, and provide little information on the dynamics of cancer cells in vivo. Preclinical investigations of CSCs would benefit from techniques that could dynamically monitor cells from their earliest appearance in tissues and throughout the processes of tumor development and metastasis in entire organs or animals. With increasing evidence of a role for cancer stem cells (CSC) in tumor initiation, proliferation, and metastasis, and a multitude of advanced imaging technologies being developed for noninvasive in vivo cell tracking, the need for imaging studies with a focus on monitoring the fate of CSCs in vivo appears clear.

Borlak scannerz